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Early HPV testing could detect sexually transmitted oral cancer (2013-06-28)

 

Antibodies to a high-risk type of human papillomavirus (HPV16) that causes mouth and throat cancers when transmitted via oral sex can be detected in blood tests many years before the clinical onset of the disease, reveals a new study from the International Agency for Research on Cancer (IARC) in cooperation with the German Cancer Research Center (DKFZ) and the United States National Cancer Institute (NCI) in an article published online by the Journal of Clinical Oncology.


 

According to the results of the study, HPV16 E6 antibodies in the blood indicate a very high risk of developing an HPV-associated cancer of the oropharynx.
“These results are very encouraging. Up to now, it was not known whether these antibodies were present in blood before the cancer became clinically detectable. If these results are confirmed, future screening tools could be developed for early detection of the disease,” explained Dr Paul Brennan, Head of the Genetics Section at IARC and the senior author of the study. “To date there are no available markers for early detection of this cancer,” he said.

Although HPV is better known for causing cervical cancer and other genital cancers, it is also responsible for an increasing number of cancers of the mouth and throat, particularly amongst men, and about 30% of oropharyngeal cancers worldwide are estimated to be HPV-related. The main type of HPV associated with these cancers is HPV16.
The issue was highlighted by Hollywood actor Michael Douglas, who said his throat cancer was caused by HPV transmitted through oral sex.

Oropharyngeal cancer includes cancers of the tonsils, the oropharynx (the oral part of the pharynx), the soft palate, and the base of the tongue.
Oropharyngeal cancer has been a relatively uncommon cancer, traditionally associated with heavy tobacco smoking and heavy alcohol consumption. But over the past few decades its occurrence has increased dramatically in many parts of the world, especially in Europe and North America. This increase is thought to be due to the growing number of infections with HPV and to changing sexual practices, such as an increase in oral sex.

In the new study, of the 135 individuals who developed oropharyngeal cancer, 47 (about one third) had HPV16 E6 antibodies in their blood up to 12 years before the onset of disease, compared with only 9 of 1599 individuals who did not develop the cancer (less than 1%). All participants were part of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which comprises more than 500 000 individuals from 10 European countries who were recruited in the 1990s and have been followed up since then.
Another significant finding of this landmark study was that patients with oropharyngeal cancer who had tested positive for antibodies against HPV16 E6 before cancer diagnosis were 3 times as likely to be alive 5 years after their diagnosis as those oropharyngeal cancer patients who had tested negative for these antibodies.

“The work shows how innovative laboratory tests may help us develop tools to prevent or detect cancer early as well as improve treatment of the disease” said Dr Christopher Wild, Director of IARC.

For more information
IARC

(MDN)

 


L'armadietto omeopatico casalingo
(del Dott. Turetta)
Quali sono i problemi o le disfunzioni che possono giovarsi di un intervento omeopatico d'urgenza e, di conseguenza, come dovrebbe essere un ideale armadietto medicinale omeopatico casalingo.


A cura di: Dott.ssa S.Cavalli, Dott. L. Colombo, Dott. U. Zuccardi Merli
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