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Endocytic reawakening of motility in jammed epithelia (2017-02-06)

Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or rigidity transition.

How cells control such phase transitions is, however, unknown.
Here researchers show that RAB5A, a key endocytic protein, is sufficient to induce large-scale, coordinated motility over tens of cells, and ballistic motion in otherwise kinetically arrested monolayers.

This is linked to increased traction forces and to the extension of cell protrusions, which align with local velocity.

Molecularly, impairing endocytosis, macropinocytosis or increasing fluid efflux abrogates RAB5A-induced collective motility.

A simple model based on mechanical junctional tension and an active cell reorientation mechanism for the velocity of self-propelled cells identifies regimes of monolayer dynamics that explain endocytic reawakening of locomotion in terms of a combination of large-scale directed migration and local unjamming.

These changes in multicellular dynamics enable collectives to migrate under physical constraints and may be exploited by tumours for interstitial dissemination.

For more information
Nature materials
Endocytic reawakening of motility in jammed epithelia
Chiara Malinverno, Salvatore Corallino, Fabio Giavazzi, Martin Bergert, Qingsen Li,Marco Leoni, Andrea Disanza, Emanuela Frittoli, Amanda Oldani, Emanuele Martini, Tobias Lendenmann, Gianluca Deflorian, Galina V. Beznoussenko, , Dimos Poulikakos, Kok Haur Ong, Marina Uroz, Xavier Trepat, Dario Parazzoli, Paolo Maiuri, Weimiao Yu, Aldo Ferrari, Roberto Cerbino, and Giorgio Scita