-

N.B.: Different languages can express different contents  -  (Italiano - English)

 

Popular heartburn pills known as proton pump inhibitors (PPIs) tied to greater mortality (2017-07-24)

Widely used heartburn drugs are associated with increased risk of death, and the longer a person uses the drugs, the greater the risk, new research suggests.

Popular heartburn pills known as proton pump inhibitors (PPIs) have also been shown to be potentially involved in cognitive decline (a study of the German Center for Neurodegenerative Diseases in Bonn, Germany Link...) and the people who take them may be more likely to develop intestinal infections than people who donít take these medications, a Scottish study suggests Link... may be more likely to develop intestinal infections than people who donít take these medications.

A new study included nearly 349,312 new users of PPIs or H2 blockers, another type of acid-suppressing drug.

They also compared PPI users and non-users within a group of nearly 3.3 million people, and PPI versus no PPI and no H2 blockers among about 2.9 million people.

The results suggest excess risk of death among PPI users.

Risk is also increased among those without gastrointestinal conditions and with prolonged duration of use.

When a person has heartburn or reflux, the studyís senior author Dr. Ziyad Al-Aly of Washington University School of Medicine in St. Louis said, possible root causes like obesity, poor diet or smoking should be addressed first.

ďAny intake or use of PPIs should be under the watchful and vigilant eye of a physician, for the smallest dose thatís effective and the shortest period of time,Ē he said.

They are often overprescribed, rarely deprescribed and frequently started inappropriately during a hospital stay, and their use extended for long-term duration without appropriate medical indication.

See also
Gastric reflux drugs are potentially involved in cognitive decline (2016-02-17)
Link...

Heartburn pills tied to bacterial gastroenteritis (2017-01-22)
Link...

For more information
Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans
Link...

Washington University School of Medicine
Link...

MDN