Informazioni notizie e comodità
per vivere meglio. Online dal 1998a cura di Marco Dal Negro
A simple urine test for the virus that causes cervical cancer could offer a less invasive and more acceptable alternative to the conventional cervical smear test.
This is based on four randomised controlled trials and a pooled analysis of these, which showed that HPV detection is more protective against grade 3 cervical intraepithelial neoplasia, CIN, and invasive cervical cancer compared with current screening methods.
Compared with cervical smear samples, urine HPV testing had an overall sensitivity (the proportion of positives correctly identified) of 87 percent, and a specificity (the proportion of negatives correctly identified) of 94 percent.
Human papillomavirus (HPV) is one of the commonest sexually transmitted infections. Up to 80% of sexually active women are infected at some point in their lives and 10-20% develop persistent infection.
Infection with specific strains of HPV has been associated with the development of cervical cancer, a preventable and treatable disease for which routine screening using a cervical cytology based method is employed to detect precancerous cervical intraepithelial neoplasia (CIN).
Despite screening, cervical cancer is still the most common malignancy in women aged less than 35, and there has been a downward trend in coverage of screening in this population. This may partly be because the current screening by cervical cytology sampling is invasive, is time consuming, and requires a clinician.
For more information
thebmj
Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis
MDN
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